North Duffield Primary nativity play collected almost £500 for charities close to kids' hearts.
Recipients were Yorkshire Cancer Research, York Against Motor Neurone Disease and Great Ormond Street Hospital Hyperinsulinism Fund.
The causes were chosen because one pupil faces a second Christmas without her dad while a fellow four-year-old suffers a life-threatening condition.
Molly Richardson's father was diagnosed with Motor Neurone Disease when she was just 14 months old.
He was left without use of his arms, little use of his legs and affected speech before his June 2005 death.
Mum Lesley said: "I was very pleased the school supported York Against Motor Neurone Disease because it's a big part of my daughter's life.
"Molly only ever knew her dad being poorly. She used to help feed him and didn't expect him to play with her. When he could speak, he read her stories and she sat on his knee.
"We talk about him quite openly now and she says he's a star in the sky. Every night when the stars are out she says 'Daddy is watching me'," added the Broadmanor mother, who regularly organises fund-raising events for the small local charity since it helped her family.
"They had one member of staff – a qualified nurse – who visited us every fortnight and gave us the equipment we needed. In the later days of my husband's life, she even slept over at our house to support me."
Harry Jewitt, of Blackwood House Farm, spent six months on a hospital ward after being diagnosed at four months old with Hyperinsulinism.
He was admitted to York District Hospital for 14 weeks before being transferred to the specialist London children's hospital he must attend at least twice yearly.
Harry underwent pancreatic surgery and suffered major fits because he produced too much insulin. He endures three daily injections and emergency medication if blood-sugar levels fall dangerously low.
Mum Sue said: "Harry's condition is extremely dangerous. It could lead to brain damage and can be fatal.
"His levels have to be constantly monitored and, if they're low, he has to eat something or use a gastrostomy tube to get milk in his body."
Sister Emma, aged ten, also attends the village school, as did 12-year-old Alicia before transferring to Barlby High. Every year since Harry was born, primary pupils have boosted Great Ormond Street funds.
After proudly watching Harry perform The Wriggly Nativity, Sue said: "The school has been so supportive. He has just started his first year and loves it.
"He does everything the other children do. We're very happy with the way he's looked after."
Key stage two pupils also performed a nativity for family and friends called Stable Manners.